The 7th International Multidisciplinary Conference on Optofluidics 2017
25–28 Jul 2017, Singapore
- Go to the Sessions
- 01. Micro-/nano-fluidics
- 02. Optical devices and systems
- 03. Biochemical sensors and assays
- 04. Optical imaging and light sources
- 05. Microfabrication and integration
- 06. Materials and modification
- 07. Wearable and implantable devices
- 08. Optofluidicand flexible displays
- 09. Energy and environment
- 10. Droplets and emulsions
- 11. Plasmonics and metamaterials
- 12. Quantum technology and science
- 13. Silicon photonics
- 14. Optical fibers and fabrics
- 15. Water science and industry
- 16. Lab on a chip
- 17. High-throughput optical imaging and spectroscopy
- 18. Other emerging and multidisciplinary researches
- Event Details
Welcome from the Chairs
Optofluidics 2017 continues a series of Conferences that provide a forum to promote scientific exchange and foster closer networks and collaborative ties between leading international optics and micro/nanofluidics researchers across cutting-edge research fields. Topics range from fundamental research to its applications in chemistry, physics, biology, materials and medicine. All the interdisciplinary topics and related aspects of Optofluidics are of interest in the conference such as micro/nanofluidics, optical devices and systems, plasmonics and metamaterial, biochemical sensors, imaging and display, fabrication and integration, energy and environment.
We anticipate that about 500–800 worldwide scientists and professionals will attend Optofluidics 2017. The conference offers plenary talks as well as contributed oral presentations and posters selected from submitted abstracts. Attendees have the opportunity to hear and present ground-breaking research, share ideas and network with colleagues and luminaries.
- Droplets and emulsions
- Optical devices and systems
- Plasmonics and metamaterials
- Quantum information and optics
- Energy and environment
- Fiber-based optofluidics
- Silicon photonics
- Lab on a chip
More information can be found at: https://www.optofluidics.sg/
02. Optical devices and systems
03. Biochemical sensors and assays
04. Optical imaging and light sources
05. Microfabrication and integration
06. Materials and modification
07. Wearable and implantable devices
08. Optofluidicand flexible displays
09. Energy and environment
10. Droplets and emulsions
11. Plasmonics and metamaterials
12. Quantum technology and science
13. Silicon photonics
14. Optical fibers and fabrics
15. Water science and industry
16. Lab on a chip
17. High-throughput optical imaging and spectroscopy
18. Other emerging and multidisciplinary researches
List of accepted submissions (439)
SINGLE CELL IMPEDANCE CYTOMETRY FOR RAPID AND LABEL-FREE MONOCYTE PHENOTYPING
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Submitted: 29 Apr 2017
Abstract: Show Abstract
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Monocytes represent a highly heterogeneous leukocyte population with the ability to differentiate into macrophages, a major cell type involved in the pathogenesis of atherosclerotic plaque in cardiovascular diseases [1,2]. Label-free analysis of their native cellular phenotypes and functions not only reduces assay cost and time, but is also essential for understanding disease progression and development of novel therapeutic strategies. Impedance cytometry is an emerging technology for high throughput cell phenotyping based on intrinsic electrical properties without the use of antibodies [3,4]. While parallel electrodes offer higher detection sensitivity as compared to co-planar electrodes [3,4], it is limited by laborious microfabrication. Herein, we present the development of an efficient microfluidics impedance cytometer using coplanar electrodes for rapid monocyte identification and phenotyping based on differentiation status.
The microfluidics impedance cytometer consists of a two-inlet, two-outlet polydimethylsiloxane (PDMS) microchannel (30 μm (width) × 20 μm (height)) bonded on patterned coplanar electrodes (20 μm in width with 20 μm separation gap). Sample and sheath fluid are injected into the device to hydrodynamically focus the cells at the channel center prior electrical detection. As the cell moves through the detection region, it disrupts the electric field generated by coplanar electrodes, thereby causing a change in electrical impedance. Using our setup (Fig. 1), the change in electrical impedance was quantified based on current change, and various cellular information were extracted at different frequencies of the excitation signal. We measured two impedance parameters namely the 1) opacity (ratio of impedance magnitude at 0.3MHz (|ZLF|) to impedance magnitude at 1.7MHz (|ZHF|)) which reflects cell membrane capacitance, and 2) |ZLF| which characterize cell size.
For identification of different blood cell types, human monocytes and lymphocytes purified using Dean Flow Fractionation (DFF) , and diluted red blood cells (RBCs) samples were separately injected into the microdevice. As shown in figure 2, different cell types were clearly differentiated based on |ZLF| due to distinct cell size differences (monocytes: 10 – 12 µm, lymphocytes: 7 – 8 µm, and red blood cells: 6 – 8 µm). Characterization of primary monocytes and leukemic THP-1 monocytic cell line also showed distinct differences in size and opacity (Fig. 3). Lastly, we compared the impedance profile of THP-1 and differentiated macrophages (PMA stimulated), and found that macrophages were more heterogeneous in size with significantly lower opacity than THP-1, demonstrating the feasibility of real-time assessment of monocyte differentiation using impedance-based sensing (Fig. 4).
In conclusion, the developed microdevice enables continuous label-free monocyte phenotyping using coplanar electrodes configuration with sufficient sensitivity. With the design simplicity and low cost fabrication, we envision our method will greatly facilitate immunology research and point-of-care monocyte profiling in patients with cardiovascular diseases.
Recycled materials for solar energy conversion
Submitted: 27 Apr 2017
Abstract: Show Abstract
Nowadays, the serious resource shortage and environmental polluting issues have attracted tremendous attention worldwide. Renewable energy such as hydroenergy, wind energy and solar energy, has been in high demanded and emerged as promising substitutions of fossil fuel. Among them, solar irradiation is the most valuable energy source in the near future, which is abundant and naturally unlimited. Researchers have devoted to seek methods to efficiently utilize solar energy and practically applied in various areas. Solar evaporation is an attractive strategy to utilize solar energy for distillation without consuming fossil fuels. Recently, different solar absorbers based on diverse materials have been extensively studied to transfer solar energy into heat for vapor generation, such as gold nanoparticles and carbon-based bilayer structures.,  However, most of the absorbers are fabricated complexly with extra cost, which limits their large-scale application.
In this work, the black polyurethane (PU) sponge with three dimensional porous structures was demonstrated as the solar light absorber for heat localization. The black PU sponge can be recycled from the used packaging materials, which are usually abandoned after utilization and difficult to decompose naturally. Every year, the production of black PU sponge as the packaging materials is numerous. Recycling and reusing the PU sponge contributes to sustainable development. Here, the PU sponge provides porous channels for fluent water supply, low thermal conductivity for heat localization and low intensity to create surface evaporation. A simple hydrophilic treatment of this PU sponge was applied to improve the wettability by being stirred in dopamine solution. An evaporation efficient of 52.2%, which is more than 3 times higher than natural evaporation process, was achieved by this modified sponge in a relatively simple and low cost method. Furthermore, it provides a new idea to reutilize the waste materials for solar energy conversion.
This work is financially supported by the Research Grants Council of Hong Kong, China (Project Number: GRF 152109/16E PolyU B-Q52T).
 Neumann, Oara, et al. "Solar vapor generation enabled by nanoparticles." Acs Nano 7.1 (2012): 42-49.
 Jiang, Qisheng, et al. "Bilayered Biofoam for Highly Efficient Solar Steam Generation." Advanced Materials 28.42 (2016): 9400-9407.
DIFFERENTIAL LABEL-FREE OPTOFLUIDIC SENSOR BASED ON POLYMERIC MICRORESONATORS FOR BIOCHEMICAL SENSING
Submitted: 21 Mar 2017
Abstract: Show Abstract
David Chauvin1, Isabelle Ledoux-Rak1 and Chi Thanh Nguyen1,*
1Laboratoire de Photonique Quantique et Moléculaire, UMR 8537, Ecole Normale Supérieure Paris-Saclay, CentraleSupélec, CNRS, Université Paris-Saclay, 61 avenue du Président Wilson 94235 Cachan, France
* Email: [email protected]; Tel.: +33-147405557
We report in this paper a new design and realization of a differential label-free optofluidic sensor based on polymeric vertically coupled microresonators for biochemical sensing. Label-free sensing based on optical polymeric microresonators has shown a very high performance in terms of detection limit . When integrated into a microfluidic circuit to form an optofluidic device, it can provide an efficient and accuracy real-time monitoring of surface sensing and chemical reaction kinetics detection [2, 3]. But when using a single transducer configuration, the transduction signal of an optofluidic sensor is perturbated by various phenomena such as thermal drift, spikes of microfluidic pressure, mechanical vibration parasites, intensity variation of optical source. These perturbations severely reduce the accuracy of sensing and then the sensor detection limit. Differential measurement permits to overcome these perturbations and therefore to improve sensor performances. The differential measurement principle is based on a simultaneous comparison of an analyte transduction signal with a reference transduction signal measured under the same physical conditions. If these two signals are submitted to the same external perturbations, we can extract the net sensing signal by subtracting the analyte transduction signal from the reference signal. To assure that these two signals are in the same experimental conditions, the design, the fabrication and the set-up of the optofluidic sensor should be optimized.
A schematic view of the device is illustrated in Figure 1, and the concatenation of microscope photographs of the optical integrated device is presented in Figure 2. This device, composed of one Y-branch directional coupler and two identical vertically coupled microracetracks, was made of polymers (SU-8 photoresist and Cytop fluorocopolymer) deposited onto a silica lower cladding covering a silicon substrate. Microfluidic channels were fabricated with another polymer (PDMS) and covered the optical integrated circuit by applying a pressure via a specific mechanical set-up. The microfluidic flows injected into two sensor channels were provided by a microfluidic station (pump and two electrovalves). The optical detection setup was realized with two separated identical photodetectors. The optical source was a tunable laser emitting at 1500-1640 nm wavelengths.
The differential optofluidic sensor has demonstrated a real-time automatic correction of the long-term thermal drift and also of the short-term external perturbations in its response. Figure 3 presents the results of a homogeneous detection of glucose solution (27.9 mM glucose in deionized water) by the sensor. On the left, we observed a thermal drift on the transduction signals extracted from measurement and reference microracetracks and on the right, the real-time differential signal. In Figure 4 are presented the result of an automatic correction of short-term interferences (spikes on the signals) on the sensor response. We can apply also this sensing scheme for the surface detection in order to overcome not only external perturbations but also some non-specific effects of surface detection. A new multiplex sensing using our optofluidic sensor for surface detection of the couple streptavidin-biotin is going to be realized.
Fig.1 Schematic view of the differential label-free optofluidic sensor based on polymeric microracetracks.
Fig. 2 Concatenation of photographs under microscope of the polymer-based microracetracks device.
Fig. 3 Optical response of the sensor with thermal drift (left) and its differential response (right).
Fig. 4 External perturbations on the transduction signals of the sensor (left) and of its differential response (right).
 Delezoide, M. Salsac, J. Lautru, H. Leh, C. Nogues, J. Zyss, M. Buckle, I. Ledoux-Rak, and C. T. Nguyen, "Vertically coupled polymer microracetrack resonators for label-free biochemical sensors", Phot. Technol. Lett., 2012, 24, 270-272.
 Delezoide, J. Lautru, J. Zyss, I. Ledoux-Rak, and C. T. Nguyen, "Vertically coupled polymer microresonators for optofluidic label-free biosensors", Proc. of SPIE, 2012, 8264, 826416-13.
3 Chauvin, I. Ledoux-Rak and C.T. Nguyen, "Optimizing detection limits of optical resonator based sensors by optimization of real-time measurement of resonators response", Proc. of SPIE, 2016, 9899, 98991J.
A novel chemical sensor using metamaterial absorber for methanol sensing aplications
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Submitted: 30 Mar 2017
Abstract: Show Abstract
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This paper presents a novel chemical sensor using a metamaterial absorber, which is composed of an Au Bottom layer, a microfluidic channel, a FR4 substrate and a split-square-cross-resonator (SSCR). The resonance generated by SSCR is extraordinarily sensitive to changes of the effective dielectric constant around the capacitive gap. Furthermore, the effective dielectric constant of the dielectric substrate is under the influence of microfluidic channels by using an infinitesimal quantity of a liquid. The proposed sensor exhibits an outstanding sensitivity by a creative SSCR structure and the Au Bottom layer. In addition, the relationship between the absorption frequency and chemical concentration is demonstrated by simulation.
Solar Fuel Production with Oxide Semiconductor Photoelectrodes
Submitted: 28 Mar 2017
Abstract: Show Abstract
About 400 semiconductor solids are known to have photocatalytic activity for water splitting. Yet there is no single material that could satisfy all the requirements for desired photocatalysts: i) suitable band gap energy (1.7 eV< Eg < 2.3 eV) for high efficiency, ii) proper band position for reduction and/or oxidation of water, iii) long-term stability in aqueous solutions, iv) low cost, v) high crystallinity, and vi) high conductivity. Hence, in the selection of photocatalytic materials, we better start from intrinsically stable materials made of earth-abundant elements. Upon selection of the candidate materials, we can also modify the materials for full utilization their potentials. The main path of efficiency loss in photoelectrochemical water splitting process is recombination of photoelectrons and holes. We discuss the material designs to minimize the e- - h+ recombination including; i) heterojunction photoanodes for effective charge separation, ii) band engineering to extend the range of light absorption, iii) metal or anion doping to improve conductivity of the semiconductor and, iv) one-dimensional nanomaterials to secure a short hole diffusion distance and vectoral electron transfer, and v) loading co-catalysts for facile charge separation. Finally, we need to construct a stand-alone solar fuel production system by combining with a solar cell in tandem, which provides bias voltage needed for the photolytic reactions making possible the fuel production only with solar energy without any external energy supply.